2-Amino-6-chlorobenzaldehyde → 1-(2-Amino-6-chlorophenyl)ethan-1-ol

HRID 2117274Notes

Reaction equation

HRID 2117274 reaction equation
[NH2:1][C:2]1[CH:9]=[CH:8][CH:7]=[C:6]([Cl:10])[C:3]=1[CH:4]=[O:5].[CH3:11][Mg]Br>C(OCC)(=O)C>[NH2:1][C:2]1[CH:9]=[CH:8][CH:7]=[C:6]([Cl:10])[C:3]=1[CH:4]([OH:5])[CH3:11]

Participants

4

Reactant 2

HCID 223995122-Amino-6-chlorobenzaldehydeHCID 178418573HCID 178418573, compound

Product 1

HCID 693154211-(2-Amino-6-chlorophenyl)ethan-1-ol

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

This compound was prepared using General Method 1 (EXAMPLE 1) from 2-amino-6-chlorobenzaldehyde (45 mg, 0.29 mmol) and methylmagnesium bromide (3 M in ether, 0.24 mL) to afford (±)-(2-amino-6-chlorophenyl)ethanol after flash chromatography (4:1 hexanes:ethyl acetate).

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-86eddd6d0ea64997b3a79bb7c1af894b
Source dataset
uspto-grants-2008_10
Patent number
US07442696B2

Reaction notes

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