HCID 68703838, compound → HCID 68707842, compound

HRID 2117380Notes

Reaction equation

HRID 2117380 reaction equation
[Cl:1][C:2]1[CH:33]=[CH:32][C:5]([C:6]([NH:8][C:9]2[C:10]([CH3:31])=[C:11]([C:18](=[O:30])[C:19]3[CH:24]=[CH:23][C:22]([N+:25]([O-])=O)=[C:21]([O:28][CH3:29])[CH:20]=3)[N:12]3[C:17]=2[CH:16]=[CH:15][CH:14]=[CH:13]3)=[O:7])=[CH:4][CH:3]=1.[H][H]>CN(C)C=O.[Pt]=O>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:6]([NH:8][C:9]2[C:10]([CH3:31])=[C:11]([C:18](=[O:30])[C:19]3[CH:24]=[CH:23][C:22]([NH2:25])=[C:21]([O:28][CH3:29])[CH:20]=3)[N:12]3[C:17]=2[CH:16]=[CH:15][CH:14]=[CH:13]3)=[O:7])=[CH:32][CH:33]=1

Participants

5

Reactant 2

HCID 68703838HCID 68703838, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 68707842HCID 68707842, compound

Reagents, catalysts & solvents 2

HCID 82844Platinum oxide (PtO)CatalystHCID 6228DimethylformamideSolvent

Procedure

A mixture of 384 mg (0.83 mmol) of 4-chloro-N-[3-(3-methoxy-4-nitrobenzoyl)-2-methylindolizin-1-yl]benzamide and 115 mg of platinum oxide in 9 ml of dimethylformamide is stirred, under 5 bar of hydrogen, at room temperature for 24 hours, and then filtered on talc. The filtrate is concentrated under reduced pressure.

Workup

  1. filtrationfiltered on talc
  2. concentrationThe filtrate is concentrated under reduced pressure

Sources & evidence

ORD record
ord-1ef58abd03d44fa89a0507f6471a7470
Source dataset
uspto-grants-2008_10
Patent number
US07442708B2

Reaction notes

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