Trifluoroacetic acid → HCID 18376152, compound

HRID 2117468Notes

Reaction equation

HRID 2117468 reaction equation
C(O)(C(F)(F)F)=O.C([O:12][C:13]([C:15]1[S:16][C:17]([CH2:20][CH2:21][CH2:22][N:23]([CH2:33][CH2:34][S:35][CH2:36][C:37]2[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=2)[S:24]([C:27]2[CH:28]=[N:29][CH:30]=[CH:31][CH:32]=2)(=[O:26])=[O:25])=[CH:18][CH:19]=1)=[O:14])(C)(C)C>C(Cl)Cl>[CH2:36]([S:35][CH2:34][CH2:33][N:23]([S:24]([C:27]1[CH:28]=[N:29][CH:30]=[CH:31][CH:32]=1)(=[O:25])=[O:26])[CH2:22][CH2:21][CH2:20][C:17]1[S:16][C:15]([C:13]([OH:14])=[O:12])=[CH:19][CH:18]=1)[C:37]1[CH:38]=[CH:39][CH:40]=[CH:41][CH:42]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acid2×HCID 54557987HCID 54557987, compound

Product 1

HCID 18376152HCID 18376152, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Conditions

Temperature
0 °C

Procedure

TFA. A solution of 5-(3-((2-benzylsulfanyl-ethyl)-(pyridine-3-sulfonyl)-amino)-propyl)-thiophene-2-carboxylic acid tert-butyl ester prepared of Example 3, Step B (0.038 g) in 1 mL CH2Cl2 was cooled to 0° C. and 1 mL TFA was added. The mixture was warmed to room temperature and was stirred for 1 h. The CH2Cl2 and TFA were removed by evaporation, azeotroping with added CH2Cl2 to yield the title compound (46.3 mg). MS 475 (M−1).

Workup

  1. temperatureThe mixture was warmed to room temperature
  2. customThe CH2Cl2 and TFA were removed by evaporation
  3. customazeotroping with added CH2Cl2

Sources & evidence

ORD record
ord-ab9576f6c9ad4e0d9065f11f39c48fe4
Source dataset
uspto-grants-2008_10
Patent number
US07442702B2

Reaction notes

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