Hydrochloric Acid → HCID 21914815, compound

HRID 2117862Notes

Reaction equation

HRID 2117862 reaction equation
C(OC(=O)[NH:7][CH2:8][CH2:9][C:10]1[CH:15]=[CH:14][C:13]([C:16]2[N:17]=[C:18]([NH:21][C:22](=[O:24])[CH3:23])[S:19][CH:20]=2)=[CH:12][CH:11]=1)(C)(C)C.[ClH:26]>C(OCC)(=O)C>[ClH:26].[NH2:7][CH2:8][CH2:9][C:10]1[CH:11]=[CH:12][C:13]([C:16]2[N:17]=[C:18]([NH:21][C:22](=[O:24])[CH3:23])[S:19][CH:20]=2)=[CH:14][CH:15]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86595592HCID 86595592, compound

Product 1

HCID 21914815HCID 21914815, compoundYield 106%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent2×

Procedure

tert-Butyl(2-{4-[2-(acetylamino)-1,3-thiazol-4-yl]phenyl}ethyl)carbamate (250 mg) was dissolved in ethyl acetate (4 mL) and 4 N hydrogen chloride in ethyl acetate (2 mL). The solvent was evaporated in vacuo. The solid was washed with ethyl acetate and ethyl ether to give N-{4-[4-(2-aminoethyl)phenyl]-1,3-thiazol-2-yl}acetamide hydrochloride (220 mg, 106%).

Workup

  1. customThe solvent was evaporated in vacuo
  2. washThe solid was washed with ethyl acetate and ethyl ether

Sources & evidence

ORD record
ord-ee56b38999b34e829a09884eaf1a8502
Source dataset
uspto-grants-2008_10
Patent number
US07442715B2

Reaction notes

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