反应详情

Thionyl chloride (0.6 ml, 7.7 mmol) was slowly added, under stirring and under argon, to a solution of 4-(Nitrooxy)butanoic acid (1.00 g, 6.7 mmol) in anhydrous Et2O (25 ml) kept 0° C. A few drops of DMF (4-5 drops) were also added under stirring to the reaction mixture and the reaction temperature was allowed to rise to r.t. (ca. 20° C.). The reaction mixture was stirred at room temperature and under argon for 5 hours. The reaction mixture was concentrated in vacuo to provide crude 4-(nitrooxy)butanoyl chloride.

1. customkept 0° C
2. customto rise to r.t.
3. custom(ca. 20° C.)
4. stirringThe reaction mixture was stirred at room temperature and under argon for 5 hours
5. concentrationThe reaction mixture was concentrated in vacuo