HCID 178500456, compound → HCID 178500457, compound

HRID 2118259Notes

Reaction equation

HRID 2118259 reaction equation
[CH3:1][O:2][C:3](=[O:28])[CH:4]=[CH:5][C@H:6]1[CH2:11][CH2:10][C@H:9]([CH2:12][N:13]([CH3:27])[S:14]([C:17]2[CH:22]=[CH:21][C:20]([C:23]([F:26])([F:25])[F:24])=[CH:19][CH:18]=2)(=[O:16])=[O:15])[CH2:8][CH2:7]1>CCOC(C)=O.[Pd]>[CH3:1][O:2][C:3](=[O:28])[CH2:4][CH2:5][C@H:6]1[CH2:11][CH2:10][C@H:9]([CH2:12][N:13]([CH3:27])[S:14]([C:17]2[CH:22]=[CH:21][C:20]([C:23]([F:26])([F:24])[F:25])=[CH:19][CH:18]=2)(=[O:16])=[O:15])[CH2:8][CH2:7]1

Participants

4

Reactant 1

HCID 178500456HCID 178500456, compound

Product 1

HCID 178500457HCID 178500457, compoundYield 96%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8857Ethyl AcetateSolvent

Procedure

1.45 g (3.5 mmol) of trans-3-(4-{[methyl-(4-trifluoromethyl-benzenesulfonyl)-amino]-methyl}-cyclohexyl)-acrylic acid methyl ester in 25 mL of EtOAc were hydrogenated at normal pressure with 5% Pd/C as the catalyst to give 1.4 g (96%) of trans-3-(4-{[methyl-(4-trifluoromethyl-benzenesulfonyl)-amino]-methyl}-cyclohexyl)-propionic acid methyl ester as white solid, MS: 422 (MH+).

Sources & evidence

ORD record
ord-c6ec9c3f882f433594bba06df7c2f72e
Source dataset
uspto-grants-2008_10
Patent number
US07442791B2

Reaction notes

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