反应详情

温度

-5 °C

3-Fluoro-5-iodoaniline (3.06 g) (WO 9623783) was added to a stirred mixture of concentrated hydrochloric acid (4 ml) and water (4 ml). Glacial acetic acid (8 ml) was added and the reaction mixture cooled to −5° C. A solution of sodium nitrite (0.99 g) in water (8 ml) was added dropwise maintaining the temperature between −5° C. and −2° C. After the addition was complete the reaction was stirred for 10 min. In the meantime glacial acetic acid (20 ml) was saturated with sulfur dioxide gas for 0.25 h, then copper(I) chloride (0.353 g) was added. Additional sulfur dioxide was bubbled through the solution until a fine suspension was obtained. The mixture was cooled to 5° C. and then treated portionwise with the diazonium salt prepared above. After stirring at room temperature for 1 h ice (50 g) was added. The mixture was extracted with ether (100 ml) and the organic phases washed with NaHCO3 solution (2×φml) then water (100 ml), dried (MgSO4) and concentrated. The residue was dissolved in THF (30 ml) at 0° C. and aqueous ammonia (0.880; 5 ml) was added. After stirring at room temperature the mixture was partitioned between EtOAc (100 ml) and water (100 ml). The organic phase was washed with brine (50 ml), dried (MgSO4) and concentrated. The residue was purified by chromatography using cyclohexane-EtOAc (5:1 then 3:1). Evaporation of the fractions and trituration of the residue with cyclohexane afforded the title compound (0.886 g). ES-ve 299 (M-H)−

1. temperaturemaintaining the temperature between −5° C. and −2° C
2. additionAfter the addition
3. customAdditional sulfur dioxide was bubbled through the solution until a fine suspension
4. customwas obtained
5. temperatureThe mixture was cooled to 5° C.
6. customprepared above
7. additionwas added
8. extractionThe mixture was extracted with ether (100 ml)
9. washthe organic phases washed with NaHCO3 solution (2×φml)
10. dry with materialwater (100 ml), dried (MgSO4)
11. concentrationconcentrated
12. dissolutionThe residue was dissolved in THF (30 ml) at 0° C.
13. additionaqueous ammonia (0.880; 5 ml) was added
14. stirringAfter stirring at room temperature the mixture
15. customwas partitioned between EtOAc (100 ml) and water (100 ml)
16. washThe organic phase was washed with brine (50 ml)
17. dry with materialdried (MgSO4)
18. concentrationconcentrated
19. customThe residue was purified by chromatography
20. customEvaporation of the fractions and trituration of the residue with cyclohexane