反应详情

A solution of 4-[(6-bromohexyl)oxy]-1-butyne (DE 3513885 A1) (288.9 mg) and 1-(cyclopentylsulfonyl)-3-iodobenzene (500 mg) in MeCN (20 ml) and triethylamine (345 μl) was treated with copper iodide (11.78 mg) and dichlorobis(triphenylphosphine)palladium(II) (43.4 mg) and stirred at room temperature for 3 h. The reaction mixture was partitioned between EtOAc and water, the organic phase was dried (MgSO4) and concentrated in vacuo. The mixture was purified by column chromatography (SPE bond elut, gradient 0 to 40% diethyl ether in cyclohexane) to afford the title compound.

1. customThe reaction mixture was partitioned between EtOAc and water
2. dry with materialthe organic phase was dried (MgSO4)
3. concentrationconcentrated in vacuo
4. customThe mixture was purified by column chromatography (SPE bond elut, gradient 0 to 40% diethyl ether in cyclohexane)