反应详情

A mixture of 7-hydroxy-4H-1-benzopyran-4-one, VII (40.5 g; 0.25 mole; prepared according to G. N. Dorafeenko and V. V. Tkachenko, Chem. Heterocyclic Compounds, 1972 (8) 935), 1-bromo-3-chloropropane (78.5 g; 0.50 mole) and anhydrous potassium carbonate (49 g; 0.50 mole) in 1000 ml of acetone was heated at reflux for 16 hours. The mixture was filtered through celite and concentrated in vacuo. The thick red oil which remained was triturated with ether, upon which 57.8 g (97%) of the title compound was obtained, mp 72°-73° C.

1. temperaturewas heated
2. temperatureat reflux for 16 hours
3. filtrationThe mixture was filtered through celite and
4. concentrationconcentrated in vacuo
5. customThe thick red oil which remained was triturated with ether, upon which 57.8 g (97%) of the title compound
6. customwas obtained