Oxygen → HCID 13923986, compound

HRID 2118489Notes

Reaction equation

HRID 2118489 reaction equation
O=O.Cl[CH2:4][CH2:5][CH2:6][CH2:7][O:8][C:9]1[CH:10]=[CH:11][C:12]2[O:17][CH:16]=[CH:15][C:14](=[O:18])[C:13]=2[CH:19]=1.[C:20]1([N:26]2[CH2:31][CH2:30][NH:29][CH2:28][CH2:27]2)[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1.C1(N)C(F)=C(F)C(F)=C(N)C=1F.Cl.Cl>>[C:20]1([N:26]2[CH2:31][CH2:30][N:29]([CH2:4][CH2:5][CH2:6][CH2:7][O:8][C:9]3[CH:10]=[CH:11][C:12]4[O:17][CH:16]=[CH:15][C:14](=[O:18])[C:13]=4[CH:19]=3)[CH2:28][CH2:27]2)[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1

Participants

5

Reactant 4

HCID 977OxygenHCID 70961-PhenylpiperazineHCID 149026Tetrafluoro-m-phenylenediamine dihydrochlorideHCID 13923968HCID 13923968, compound

Product 1

HCID 13923986HCID 13923986, compound

Procedure

The title compound was prepared by the method described above for the compounds of Formula I wherein X is oxygen. Thus, 6-(4-chlorobutoxy)-4H-1-benzopyran-4-one, as prepared above in Preparation 3, (3.79 g; 15 mmol) was reacted with 1-phenylpiperazine (2.59 g; 16 mmol) in the usual way, yielding 3.5 g of 6-[4-(4-phenyl-1-piperazinyl)butoxy]-4H-1-benzopyran-4-one as its dihydrochloride salt, mp 193°-195° C. (See Scheme I.)

Workup

  1. customThe title compound was prepared by the method

Sources & evidence

ORD record
ord-b021ec1be7824bd08c6d470cb9b39980
Source dataset
uspto-grants-1987_07
Patent number
US04678787

Reaction notes

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