Potassium Carbonate → HCID 178521529, compound

HRID 2118490Notes

Reaction equation

HRID 2118490 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9]1([CH2:12][N:13]2[CH:17]=[N:16][CH:15]=[N:14]2)[CH2:11][O:10]1.[SH:18][C:19]1[N:23]=[CH:22][NH:21][N:20]=1.C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O>[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9]([OH:10])([CH2:11][S:18][C:19]1[N:23]=[CH:22][NH:21][N:20]=1)[CH2:12][N:13]1[CH:17]=[N:16][CH:15]=[N:14]1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 104232291H-1,2,4-Triazole, 1-[[2-(2,4-dichlorophenyl)oxiranyl]methyl]-HCID 178527894HCID 178527894, compound

Product 1

HCID 178521529HCID 178521529, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-yl-methyl)oxirane methanesulphonte salt (5 g, 0.0137 m), 3-mercapto-1,2,4-triazole (5 g, 0.05 m), and anhydrous potassium carbonate (14 g, 0.1 m) were stirred in dry N,N-dimethylformamide (100 ml) at 80° C. for 1 hour. The solvent was then evaporated and the residue was dissolved in water and extracted with methylene chloride. The combined extracts were washed once with dilute sodium bicarbonate solution, dried (MgSO4), and evaporated to give a solid residue which was recrystallized from isopropanol/water to give the title compound, 3.7 g (74%); m.p. 180°-182° C.

Workup

  1. customThe solvent was then evaporated
  2. dissolutionthe residue was dissolved in water
  3. extractionextracted with methylene chloride
  4. washThe combined extracts were washed once with dilute sodium bicarbonate solution
  5. dry with materialdried (MgSO4)
  6. customevaporated
  7. customto give a solid residue which
  8. customwas recrystallized from isopropanol/water

Sources & evidence

ORD record
ord-1eb397140af442018b1a40107eb70831
Source dataset
uspto-grants-1987_07
Patent number
US04678789

Reaction notes

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