Chloral Hydrate → HCID 20194016, compound

HRID 2118516Notes

Reaction equation

HRID 2118516 reaction equation
[Cl:1][C:2]1[CH:21]=[CH:20][CH:19]=[CH:18][C:3]=1[CH2:4][NH:5][CH2:6][CH2:7][C:8]1[CH:13]=[CH:12][C:11]([O:14][CH3:15])=[C:10]([O:16][CH3:17])[CH:9]=1.ClC(Cl)(Cl)[CH:24](O)[OH:25]>C(OCC)(=O)C>[CH:24]([N:5]([CH2:6][CH2:7][C:8]1[CH:13]=[CH:12][C:11]([O:14][CH3:15])=[C:10]([O:16][CH3:17])[CH:9]=1)[CH2:4][C:3]1[CH:18]=[CH:19][CH:20]=[CH:21][C:2]=1[Cl:1])=[O:25]

Participants

4

Reactant 2

HCID 2707Chloral HydrateHCID 2168799HCID 2168799, compound

Product 1

HCID 20194016HCID 20194016, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Conditions

Temperature
120 °C

Procedure

N-(2-chlorobenzyl)-2-(3,4-dimethoxy-phenyl)-ethylamine (88.4 g, 0.29 mol) is mixed with chloral hydrate (52.5 g, 0.34 mol) and heated (120° C.) for 30 minutes. After cooling, ethyl acetate is added and the mixture is washed with water, dried and evaporated. Yield: 103 g.

Workup

  1. temperatureAfter cooling
  2. washthe mixture is washed with water
  3. customdried
  4. customevaporated

Sources & evidence

ORD record
ord-f81acec3ed12420f98405658dec47e3f
Source dataset
uspto-grants-1987_07
Patent number
US04678792

Reaction notes

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