Hydrochloric Acid → HCID 21246158, compound

HRID 2118532Notes

Reaction equation

HRID 2118532 reaction equation
[C:1]([NH:5][CH2:6][CH:7]([OH:26])[CH2:8][O:9][C:10]1[CH:15]=[C:14]([O:16][CH3:17])[CH:13]=[CH:12][C:11]=1[C:18]1[N:23]=[N:22][C:21]([O:24]C)=[CH:20][CH:19]=1)([CH3:4])([CH3:3])[CH3:2].Cl.C(=O)([O-])[O-].[K+].[K+]>>[C:1]([NH:5][CH2:6][CH:7]([OH:26])[CH2:8][O:9][C:10]1[CH:15]=[C:14]([O:16][CH3:17])[CH:13]=[CH:12][C:11]=1[C:18]1[CH:19]=[CH:20][C:21](=[O:24])[NH:22][N:23]=1)([CH3:4])([CH3:2])[CH3:3]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 11430Potassium CarbonateHCID 21246153HCID 21246153, compound

Product 1

HCID 21246158HCID 21246158, compound

Procedure

6-[2-(3-t-Butylamino-2-hydroxypropoxy)-4-methoxyphenyl]-3-methoxypyridazine was hydrolysed with hydrochloric acid in a manner similar to that described in Example 3 vi). Addition of an excess of potassium carbonate to the cooled solution afforded the title compound which was recrystallised from ethanol/ether, m.p. 159°-161° C.

Sources & evidence

ORD record
ord-6f709c130e96484f913415cdaabcc682
Source dataset
uspto-grants-1987_07
Patent number
US04678786

Reaction notes

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