Water → HCID 20192899, compound

HRID 2118655Notes

Reaction equation

HRID 2118655 reaction equation
[CH2:1](N)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][NH2:7].Cl[C:10]1[C:19]2[C:14](=[CH:15][C:16]([Cl:20])=[CH:17][CH:18]=2)[N:13]=[CH:12][CH:11]=1.O>C(Cl)Cl>[NH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2][CH2:1][C:10]1[C:19]2[C:14](=[CH:15][C:16]([Cl:20])=[CH:17][CH:18]=2)[N:13]=[CH:12][CH:11]=1

Participants

5

Reactant 3

HCID 962WaterHCID 68664,7-DichloroquinolineHCID 16402Hexamethylenediamine

Product 1

HCID 20192899HCID 20192899, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Conditions

Temperature
150 °C

Procedure

17.1 Grams of hexane-1,6-diamine and 4.3 g of 4,7-dichloroquinoline were mixed together and heated to 150° C. for four hours. The reaction was cooled and water and methylene chloride were then added. The organic phase was washed, dried with anhydrous magnesium sulfate and evaporated thereby affording 1-amino-6-(7-chloro-4-quinolinyl)hexane having a melting point of 133°-134°.

Workup

  1. temperatureThe reaction was cooled
  2. washThe organic phase was washed
  3. dry with materialdried with anhydrous magnesium sulfate
  4. customevaporated

Sources & evidence

ORD record
ord-2dcff2bd2b0a4ac9b39f3a55291eb36e
Source dataset
uspto-grants-1987_07
Patent number
US04680300

Reaction notes

Loading…