Sodium Iodide → HCID 13633449, compound

HRID 2118674Notes

Reaction equation

HRID 2118674 reaction equation
[C:1]1([C:7]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)([CH:9]2[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]2)[OH:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Br[CH2:22][CH2:23][N:24]1[C:28]2[CH:29]=[CH:30][CH:31]=[CH:32][C:27]=2[NH:26][C:25]1=[O:33].C(=O)([O-])[O-].[Na+].[Na+].[I-].[Na+]>C(C(C)=O)C(C)C>[OH:8][C:7]([C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)([C:1]1[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1)[CH:9]1[CH2:14][CH2:13][N:12]([CH2:22][CH2:23][N:24]2[C:28]3[CH:29]=[CH:30][CH:31]=[CH:32][C:27]=3[NH:26][C:25]2=[O:33])[CH2:11][CH2:10]1

Participants

6

Reactant 4

HCID 5238Sodium IodideHCID 10340Sodium CarbonateHCID 15723AzacyclonolHCID 136334481-(2-Bromoethyl)-1,3-dihydro-2H-benzimidazol-2-one

Product 1

HCID 13633449HCID 13633449, compound

Reagents, catalysts & solvents 1

HCID 7909Methyl Isobutyl KetoneSolvent

Procedure

A mixture of 2.7 g (0.01 mole) of alpha,alpha-diphenyl-4-piperidinemethanol, 2.4 g (0.01 mole) of 1-(1-bromo-2-ethyl)-2-benzimidazolone, 1.2 g of sodium carbonate (Na2CO3), and a crystal of sodium iodide in 75 ml of methyl isobutyl ketone is heated at reflux temperature for 18 h.

Workup

  1. temperatureat reflux temperature for 18 h.

Sources & evidence

ORD record
ord-0223bb8ed0f14cafbd55fe9435efec97
Source dataset
uspto-grants-1987_07
Patent number
US04680296

Reaction notes

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