反应详情

A solution of 32.4 g of 2-tert-butyl-5-chloro-6-nitrobenzothiazole described in Example 5, in 300 ml of dimethyl sulfoxide, is stirred and heated at 140° for 6 hours with 12.8 g of 4-methylpiperidine and 35.8 g of anhydrous potassium carbonate, cooled and poured into water. The solid obtained is dissolved in chloroform and filtered through a silica gel column. The filtrate is evaporated to give 2-tert-butyl-5-[4-methylpiperidin-1-yl]-6-nitrobenzothiazole melting at 116°-120°.

1. temperaturecooled
2. customThe solid obtained
3. filtrationfiltered through a silica gel column
4. customThe filtrate is evaporated