Water → HCID 15930829, compound

HRID 2118775Notes

Reaction equation

HRID 2118775 reaction equation
[OH2:1].C1C=CC(P([C:15]2[CH:20]=CC=CC=2)C2C=CC=CC=2)=CC=1.[NH:21]1[CH2:26][CH2:25][O:24][CH2:23][CH2:22]1>>[OH:24][CH2:25][CH2:26][N:21]1[CH2:15][CH2:20][O:1][CH2:23][CH2:22]1.[O:24]1[CH2:25][CH2:26][N:21]([CH:22]([N:21]2[CH2:15][CH2:20][O:1][CH2:25][CH2:26]2)[CH3:23])[CH2:22][CH2:23]1

Participants

5

Reactant 3

HCID 962WaterHCID 8083MorpholineHCID 11776Triphenylphosphine

Product 2

HCID 611632-MorpholinoethanolHCID 15930829HCID 15930829, compoundYield 87%

Procedure

The procedure of Example 1 was repeated using a catalyst system consisting of 39 mg RuCl3 ×H2O (43.1% Ru, 1.7×10-4 mol Ru) and 226 mg PPh3 (8.6×10-4 mol). In this run, the maximum reaction pressure was 71 psig which, on cooling to room temperature. dropped to 27 psig. Analysis of reaction products showed 100% conversion of morpholine with yields of hydroxyethylmorpholine and bismorpholinoethane being 87% and 7%, respectively.

Workup

  1. customIn this run, the maximum reaction pressure
  2. additiondropped to 27 psig
  3. customAnalysis of reaction products

Sources & evidence

ORD record
ord-1185526a2fc24c4f8bbbee68797b3472
Source dataset
uspto-grants-1987_07
Patent number
US04680393

Reaction notes

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