反应详情

A mixture of 0.07 mole (20.7 g) of 2,4'-dichloro-5-nitrobenzophenone, 0.1 mole (11.4 ml) of 4-methyl-piperidine and 10 g of K2CO3 in 100 ml of anhydrous ethanol is heated for 3 hours to reflux. After cooling of the reaction medium, the resulting precipitate is filtered, washed in water, dried then re-crystallized in ethanol. 18 g (yield: 71.7%) of the expected product are thus obtained. M.P. 136° C.

1. temperatureis heated for 3 hours
2. temperatureto reflux
3. temperatureAfter cooling of the reaction medium
4. filtrationthe resulting precipitate is filtered
5. washwashed in water
6. customdried
7. customthen re-crystallized in ethanol