Potassium Carbonate → HCID 20191667, compound

HRID 2118994Notes

Reaction equation

HRID 2118994 reaction equation
[NH:1]1[CH2:6][CH2:5][CH:4]([CH:7]2[C:13]3=[CH:14][CH:15]=[CH:16][N:12]3[CH2:11][C:10]3[CH:17]=[CH:18][CH:19]=[CH:20][C:9]=3[O:8]2)[CH2:3][CH2:2]1.Cl[CH2:22][CH2:23][CH2:24][C:25]1[C:29]2[CH:30]=[CH:31][C:32]([F:34])=[CH:33][C:28]=2[O:27][N:26]=1.[C:35]([O-:38])([O-:37])=O.[K+].[K+]>CN(C=O)C>[C:9]([OH:8])(=[O:27])[C:35]([OH:38])=[O:37].[F:34][C:32]1[CH:31]=[CH:30][C:29]2[C:25]([CH2:24][CH2:23][CH2:22][N:1]3[CH2:2][CH2:3][CH:4]([CH:7]4[C:13]5=[CH:14][CH:15]=[CH:16][N:12]5[CH2:11][C:10]5[CH:17]=[CH:18][CH:19]=[CH:20][C:9]=5[O:8]4)[CH2:5][CH2:6]3)=[N:26][O:27][C:28]=2[CH:33]=1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 109108803-(3-Chloropropyl)-6-fluorobenzo[d]isoxazoleHCID 1368935811-(piperdin-4-yl)-5H,11H-pyrrolo[2,1-c][1,4]benzoxazepine

Product 1

HCID 20191667HCID 20191667, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

To 50 ml dry DMF were added 11-(piperidin-4-yl)-5H,11H-pyrrolo[2,1-c][1,4]benzoxazepine (3.0 g, 0.0112 mole), 3-(3-chloropropyl)-6-fluoro-1,2-benzisoxazole (4.2 g, 0.02 mole), milled K2CO3 (10 g, 0.07 mole) and KI (0.01 g).

Sources & evidence

ORD record
ord-d876ca64488a4b01982079fb507b35a3
Source dataset
uspto-grants-1987_07
Patent number
US04681879

Reaction notes

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