Tetrahydrofuran → HCID 13689377, compound

HRID 2119002Notes

Reaction equation

HRID 2119002 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:27]=[CH:28][C:29]=1[Cl:30])[C:5]([N:7]1[CH2:12][CH2:11][CH:10]([CH:13]2[C:19]3=[CH:20][CH:21]=[CH:22][N:18]3[CH2:17][C:16]3[CH:23]=[CH:24][CH:25]=[CH:26][C:15]=3[O:14]2)[CH2:9][CH2:8]1)=O.[H-].[Al+3].[Li+].[H-].[H-].[H-].C1COCC1>>[Cl:1][C:2]1[CH:3]=[C:4]([CH:27]=[CH:28][C:29]=1[Cl:30])[CH2:5][N:7]1[CH2:12][CH2:11][CH:10]([CH:13]2[C:19]3=[CH:20][CH:21]=[CH:22][N:18]3[CH2:17][C:16]3[CH:23]=[CH:24][CH:25]=[CH:26][C:15]=3[O:14]2)[CH2:9][CH2:8]1

Participants

4

Reactant 3

HCID 8028TetrahydrofuranHCID 13689376HCID 13689376, compoundHCID 21226445Aluminium lithium hydride

Product 1

HCID 13689377HCID 13689377, compound

Procedure

To a cooled solution of 11-[1-(3,4-dichlorobenzoyl)piperidin-4-yl]-5H,11H-pyrrolo[2,1-c][1,4]benzoxazepine (4.8 g; 0.011 mole in 100 ml THF) was added a 1 molar solution of lithium aluminum hydride in THF (17 ml, 0.017 mole). This was then stirred at room temperature for 1 hour.

Sources & evidence

ORD record
ord-db728f6ebd484b5fadeef5b3f5c502ba
Source dataset
uspto-grants-1987_07
Patent number
US04681879

Reaction notes

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