Sodium hydride → HCID 13851472, compound

HRID 2119017Notes

Reaction equation

HRID 2119017 reaction equation
[H-].[Na+].F[C:4]1[CH:25]=[CH:24][CH:23]=[CH:22][C:5]=1[CH2:6][N:7]1[C:11]([CH3:12])=[CH:10][CH:9]=[C:8]1[CH:13]([CH:15]1[CH2:20][CH2:19][N:18]([CH3:21])[CH2:17][CH2:16]1)[OH:14]>>[CH3:12][C:11]1[N:7]2[C:8]([CH:13]([CH:15]3[CH2:20][CH2:19][N:18]([CH3:21])[CH2:17][CH2:16]3)[O:14][C:4]3[CH:25]=[CH:24][CH:23]=[CH:22][C:5]=3[CH2:6]2)=[CH:9][CH:10]=1

Participants

3

Reactant 2

HCID 24758Sodium hydrideHCID 20191699HCID 20191699, compound

Product 1

HCID 13851472HCID 13851472, compound

Conditions

Temperature
70 °C

Procedure

To a suspension of sodium hydride (3.20 g, 60% dispersion in oil, washed twice with hexane) in 20 ml dimethylformamide/benzene (20:80) was added a solution of [1-(2-fluorobenzyl)-5-methylpyrrol-2-yl][(1-methyl)piperidin-4-yl]methanol (15.45 g, 0.088 mole) in 80 ml of the same solvent. This was heated at 70° C. for 5 hours.

Workup

  1. washwashed twice with hexane) in 20 ml dimethylformamide/benzene (20:80)

Sources & evidence

ORD record
ord-aaad76e4d7d84c68a812a896ebdf46d8
Source dataset
uspto-grants-1987_07
Patent number
US04681879

Reaction notes

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