Potassium tert-butoxide → HCID 13923639, compound

HRID 2119018Notes

Reaction equation

HRID 2119018 reaction equation
[Cl:1][C:2]1[C:7]([CH2:8][N:9]2[CH:13]=[CH:12][CH:11]=[C:10]2[CH:14]([CH:16]2[CH2:21][CH2:20][N:19]([CH3:22])[CH2:18][CH2:17]2)[OH:15])=[C:6](F)[CH:5]=[CH:4][CH:3]=1.CC(C)([O-])C.[K+]>O1CCCC1>[Cl:1][C:2]1[C:7]2[CH2:8][N:9]3[CH:13]=[CH:12][CH:11]=[C:10]3[CH:14]([CH:16]3[CH2:21][CH2:20][N:19]([CH3:22])[CH2:18][CH2:17]3)[O:15][C:6]=2[CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 23665647Potassium tert-butoxideHCID 57295810HCID 57295810, compound

Product 1

HCID 13923639HCID 13923639, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Conditions

Temperature
50 °C

Procedure

To a solution of [1-(6-chloro-2-fluorobenzyl)-2-pyrryl](1-methylpiperidin-4-yl)methanol (25.1 g; 0.075 mole) in 230 ml of tetrahydrofuran was added potassium tert-butoxide (9.2 g; 0.082 mole). This was stirred for 0.5 hour at 50° C.

Sources & evidence

ORD record
ord-bee60824c923474b80df4ceae6dfa1e3
Source dataset
uspto-grants-1987_07
Patent number
US04681879

Reaction notes

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