Potassium tert-butoxide → HCID 13923640, compound

HRID 2119019Notes

Reaction equation

HRID 2119019 reaction equation
F[C:2]1[CH:22]=[C:21]([F:23])[CH:20]=[CH:19][C:3]=1[CH2:4][N:5]1[CH:9]=[CH:8][CH:7]=[C:6]1[CH:10]([CH:12]1[CH2:17][CH2:16][N:15]([CH3:18])[CH2:14][CH2:13]1)[OH:11].CC(C)([O-])C.[K+]>O1CCCC1.C(OCC)(=O)C>[F:23][C:21]1[CH:20]=[CH:19][C:3]2[CH2:4][N:5]3[CH:9]=[CH:8][CH:7]=[C:6]3[CH:10]([CH:12]3[CH2:17][CH2:16][N:15]([CH3:18])[CH2:14][CH2:13]3)[O:11][C:2]=2[CH:22]=1

Participants

5

Reactant 2

HCID 23665647Potassium tert-butoxideHCID 57065866HCID 57065866, compound

Product 1

HCID 13923640HCID 13923640, compound

Reagents, catalysts & solvents 2

HCID 8028TetrahydrofuranSolventHCID 8857Ethyl AcetateSolvent

Conditions

Temperature
50 °C

Procedure

To a solution of [1-(2,4-difluorobenzyl)-2-pyrryl]-(1-methylpiperidin-4-yl)methanol(28.1 g; 0.088 mole) in 320 ml of tetrahydrofuran was added potassium tert-butoxide (11.3 g; 0.10 mole). The reaction mixture was warmed (50° C.) for 15 minutes, diluted with ethyl acetate and washed with water (2×). The organics were then dried (saturated NaCl solution, anhydrous MgSO4). This was concentrated to a solid, m.p. 115°-120° C.

Workup

  1. washwashed with water (2×)
  2. dry with materialThe organics were then dried (saturated NaCl solution, anhydrous MgSO4)
  3. concentrationThis was concentrated to a solid, m.p. 115°-120° C.

Sources & evidence

ORD record
ord-3734f6f3dbfb41ad8769b5e671c1a359
Source dataset
uspto-grants-1987_07
Patent number
US04681879

Reaction notes

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