Tetrahydrofuran → 2-anilino-7-chloro-6-fluoro-1-phenyl-5-(trifluoroacetyl)-1,8-naphthyridin-4(1H)-one

HRID 211905ノート

反応式

[CH2:58]1[O:59][CH2:60][CH2:61][CH2:62]1.[CH3:11][N:12]([CH3:13])[CH2:14][CH2:15][N:16]([CH3:17])[CH3:18].[CH3:19][CH2:20][CH2:21][CH2:22][Li:23].[CH3:1][CH:2]1[CH2:3][CH2:4][CH2:5][N:6]([CH3:7])[C:8]1([CH3:9])[CH3:10].[F:50][C:51]([C:52](=[O:53])[O:54][CH3:55])([F:56])[F:57].[NH:24]([c:25]1[cH:26][cH:27][cH:28][cH:29][cH:30]1)[c:31]1[n:32](-[c:44]2[cH:45][cH:46][cH:47][cH:48][cH:49]2)[c:33]2[n:34][c:35]([Cl:43])[c:36]([F:42])[cH:37][c:38]2[c:39](=[O:41])[cH:40]1>>[NH:24]([c:25]1[cH:26][cH:27][cH:28][cH:29][cH:30]1)[c:31]1[n:32](-[c:44]2[cH:45][cH:46][cH:47][cH:48][cH:49]2)[c:33]2[n:34][c:35]([Cl:43])[c:36]([F:42])[c:37]([C:52]([C:51]([F:50])([F:56])[F:57])=[O:53])[c:38]2[c:39](=[O:41])[cH:40]1