Trifluoroacetic acid → HCID 69891115, compound

HRID 2119366Notes

Reaction equation

HRID 2119366 reaction equation
FC(F)(F)C(O)=O.O[C:9]([C:25]1[CH:30]=[CH:29][CH:28]=[C:27]([OH:31])[CH:26]=1)([C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)[CH2:10][CH2:11][N:12]1[CH2:18][CH2:17][CH2:16][NH:15][CH2:14][CH2:13]1>C(Cl)Cl>[OH:31][C:27]1[CH:26]=[C:25]([C:9]([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)=[CH:10][CH2:11][N:12]2[CH2:18][CH2:17][CH2:16][NH:15][CH2:14][CH2:13]2)[CH:30]=[CH:29][CH:28]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 23441016HCID 23441016, compound

Product 1

HCID 69891115HCID 69891115, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Trifluoroacetic acid (4.75 mL) was added to a solution of 1-[3-hydroxy-3-(3-hydroxyphenyl)-3-phenylpropyl]homopiperazine (Compound No. 295, 60 mg, 0.184 mmol) in CH2Cl2 (0.25 mL). The reaction mixture was stirred at room temperature for 2.5 h. The trifluoroacetic acid was evaporated to afford 1-[3-(3-hydroxyphenyl)-3-phenyl-2-propenyl]homopiperazine as a colorless oil used without further purification.

Workup

  1. customThe trifluoroacetic acid was evaporated

Sources & evidence

ORD record
ord-78aa8182be53469796f47ee7c1e73ca5
Source dataset
uspto-grants-2004_02
Patent number
US06686353B1

Reaction notes

Loading…