Potassium Carbonate → HCID 15839197, compound

HRID 2119430Notes

Reaction equation

HRID 2119430 reaction equation
[OH:1][CH:2]([C:7]([C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)[CH3:8])[C:3]([O:5][CH3:6])=[O:4].C([O-])([O-])=O.[K+].[K+].CS([C:31]1[N:36]=[C:35]([O:37][CH3:38])[CH:34]=[C:33]([O:39][CH3:40])[N:32]=1)(=O)=O>CN(C=O)C>[CH3:40][O:39][C:33]1[CH:34]=[C:35]([O:37][CH3:38])[N:36]=[C:31]([O:1][CH:2]([C:7]([C:15]2[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=2)([C:9]2[CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=2)[CH3:8])[C:3]([O:5][CH3:6])=[O:4])[N:32]=1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 8383634,6-Dimethoxy-2-(methylsulfonyl)pyrimidineHCID 11737309Methyl 2-hydroxy-3,3-diphenylbutyrate

Product 1

HCID 15839197HCID 15839197, compoundYield 100.2%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

1.2 g (4.4 mmol) of methyl 2-hydroxy-3,3-diphenylbutyrate were dissolved in 10 ml of absolute DMF and, under nitrogen, 1.2 g (8.8 mmol) of K2CO3 and 0.97 g (4.4 mmol) of 2-methanesulfonyl-4,6-dimethoxypyrimidine were added. The mixture was stirred at room temperature for 16 hours. It was then evaporated, and the residue was taken up in water and extracted three times with ethyl acetate. The combined organic phases were dried over MgSO4 and concentrated. 1.8 g of crude product were obtained and were reacted further without purification.

Workup

  1. customIt was then evaporated
  2. extractionextracted three times with ethyl acetate
  3. dry with materialThe combined organic phases were dried over MgSO4
  4. concentrationconcentrated

Sources & evidence

ORD record
ord-e7eedea2322242bbbea9abd0546939d5
Source dataset
uspto-grants-2004_02
Patent number
US06686369B1

Reaction notes

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