反应详情

温度

80 °C

A mixture of 6-methoxy-2-(methylethyl)-1-(4-hydroxybenzyl)-1,2,3,4-tetrahydroisoquinoline (0.212 g, 0.68 mmol), 2-chloroethylpiperidine hydrochloride (0.25 g, 1.36 mmol), and potassium carbonate (0.47 g, 3.4 mmol) in dimethylformamide (10 mL) was heated at 80° C. overnight. After cooling to room temperature, the mixture was poured into water and extracted with CH2Cl2. The organic layer was dried over MgSO4, filtered, and concentrated. The residue was then purified by chromatography (SiO2, 0-15% methanol/CH2Cl2) to provide the title compound (0.201 g, 70% yield): ES−MS (m/z) 423 [M+H]+.

1. temperatureAfter cooling to room temperature
2. extractionextracted with CH2Cl2
3. dry with materialThe organic layer was dried over MgSO4
4. filtrationfiltered
5. concentrationconcentrated
6. customThe residue was then purified by chromatography (SiO2, 0-15% methanol/CH2Cl2)