Hydrochloric Acid → HCID 23442618, compound

HRID 2119600Notes

Reaction equation

HRID 2119600 reaction equation
C(OC(=O)[NH:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][NH:13][C:14]1[S:15][C:16]([C:20](=[O:28])[C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=2[CH3:27])=[C:17]([CH3:19])[N:18]=1)(C)(C)C.[ClH:30]>O1CCOCC1>[ClH:30].[NH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][NH:13][C:14]1[S:15][C:16]([C:20]([C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=2[CH3:27])=[O:28])=[C:17]([CH3:19])[N:18]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 20616913HCID 20616913, compound

Product 1

HCID 23442618HCID 23442618, compoundYield 99%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

A solution of 170 mg (0.4 mmol) {5-[4-Methyl-5-(2-methyl-benzoyl)-thiazol-2-ylamino]-pentyl}-carbamic acid tert-butyl ester in 2 ml dioxane was treated with 1 ml 4N HCl in dioxane and allowed to react for 5 h at room temperature. The mixture was evaporated under reduced pressure to afford 143 mg (99%) of the title compound.

Workup

  1. customto react for 5 h at room temperature
  2. customThe mixture was evaporated under reduced pressure

Sources & evidence

ORD record
ord-37758d9a98014eb6b23dc10e117b6d94
Source dataset
uspto-grants-2004_02
Patent number
US06686381B2

Reaction notes

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