Water → HCID 23442339, compound

HRID 2119647Notes

Reaction equation

HRID 2119647 reaction equation
C[O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[C:10]3[C:11](=[O:23])[C:12]4[N:21]([CH3:22])[N:20]=[CH:19][C:13]=4[NH:14][C:15]=3[CH:16]=[CH:17][CH:18]=2)=[CH:5][CH:4]=1.O>Br.C(O)(=O)C>[OH:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[C:10]3[C:11](=[O:23])[C:12]4[N:21]([CH3:22])[N:20]=[CH:19][C:13]=4[NH:14][C:15]=3[CH:16]=[CH:17][CH:18]=2)=[CH:5][CH:4]=1

Participants

5

Reactant 2

HCID 962WaterHCID 23442332HCID 23442332, compound

Product 1

HCID 23442339HCID 23442339, compoundYield 94%

Reagents, catalysts & solvents 2

HCID 176Acetic AcidSolventHCID 260Hydrogen BromideSolvent

Procedure

A mixture of 8-(4-methoxyphenyl)-1-methyl-1,4-dihydro-9H-pyrazolo[4,3-b]quinolin-9-one (EXAMPLE 38, step 3, 41 mg, 0.14 mmol) in a mixture of 48% hydrobromic acid (1 ml) and acetic acid (1 ml) was refluxed for 7 h. After cooling to room temperature, water was added to the mixture. The formed solid was collected by filtration to give 37 mg (94%) of the title compound as a solid.

Workup

  1. temperaturewas refluxed for 7 h
  2. filtrationThe formed solid was collected by filtration

Sources & evidence

ORD record
ord-733d20a4c5f64f23b1af244eb9a8db08
Source dataset
uspto-grants-2004_02
Patent number
US06686373B2

Reaction notes

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