反应详情

Under argon atmosphere, a solution of 11.12 g of 2,5-di-t-butylhydroquinone and 10.1 ml of anhydrous trimethylacetic acid in 200 ml of acetonitrile was stirred with a catalytic amount of sulfuric acid at room temperature for a whole day and night. After the reaction mixture was evaporated under reduced pressure, the concentrate was dissolved in diisopropyl ether. This solution was washed with a saturated aqueous sodium bicarbonate solution, then saturated brine, dried over anhydrous magnesium sulfate, and then concentrated. The concentrate was purified by silica gel column chromatography (in n-hexane containing 5% ethyl acetate) to give 11.9 g of 2,5-di-t-butyl-4-trimethylacetoxyphenol as a white solid (yield 78%).

1. customAfter the reaction mixture was evaporated under reduced pressure
2. dissolutionthe concentrate was dissolved in diisopropyl ether
3. washThis solution was washed with a saturated aqueous sodium bicarbonate solution
4. dry with materialsaturated brine, dried over anhydrous magnesium sulfate
5. concentrationconcentrated
6. customThe concentrate was purified by silica gel column chromatography (in n-hexane containing 5% ethyl acetate)