3-Chloro-2-methyl-1-propene → HCID 69892168, compound

HRID 2119706Notes

Reaction equation

HRID 2119706 reaction equation
[H-].[Na+].[C:3]([C:7]1[C:21]([OH:22])=[CH:20][C:10]2[CH2:11][C:12]3([O:19][C:9]=2[CH:8]=1)[CH2:18][CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]3)([CH3:6])([CH3:5])[CH3:4].[CH2:23](Cl)[C:24](=[CH2:26])[CH3:25]>CN(C)C=O>[C:3]([C:7]1[C:21]([O:22][CH2:25][C:24]([CH3:26])=[CH2:23])=[CH:20][C:10]2[CH2:11][C:12]3([O:19][C:9]=2[CH:8]=1)[CH2:18][CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]3)([CH3:6])([CH3:4])[CH3:5]

Participants

5

Reactant 3

HCID 112413-Chloro-2-methyl-1-propeneHCID 24758Sodium hydrideHCID 12094374HCID 12094374, compound

Product 1

HCID 69892168HCID 69892168, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

0.13 g of oily sodium hydride and 0.74 g of 6-t-butyl-5-hydroxy-2,3-dihydrobenzofuran-2-spiro-1′-cycloheptane synthesized in Example 7 were treated with 0.32 ml of methallyl chloride in dimethylformamide in the same manner as in Example 8-1) to give 0.89 g of 6-t-butyl-5-(2-methyl-2-propenyloxy)-2,3-dihydrobenzofuran-2-spiro-1′-cycloheptane as a colorless oil (quantitative).

Sources & evidence

ORD record
ord-e3d826c5c13441fab3624b83246d6229
Source dataset
uspto-grants-2004_02
Patent number
US06686389B2

Reaction notes

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