Nitrogen → HCID 69765744, compound

HRID 2119777Notes

Reaction equation

N#N.[C@@H:3]1([N:12]2[C:21](=[O:22])[C:20]3[NH:19][CH:18]=[N:17][C:16]=3[N:15]=[C:13]2[NH2:14])[O:9][C@H:8]([CH2:10][OH:11])[C@@H:6]([OH:7])[C@@H:4]1[OH:5].[C:23](Cl)(=[O:27])[CH:24]([CH3:26])[CH3:25]>>[C@@H:3]1([N:12]2[C:21](=[O:22])[C:20]3[NH:19][CH:18]=[N:17][C:16]=3[N:15]=[C:13]2[NH:14][C:23](=[O:27])[CH:24]([CH3:26])[CH3:25])[O:9][C@H:8]([CH2:10][OH:11])[C@@H:6]([OH:7])[C@@H:4]1[OH:5]

Participants

Reactant 3

HCID 947Nitrogen

HCID 62325Isobutyryl chloride

HCID 53718478HCID 53718478, compound

Product 1

HCID 69765744HCID 69765744, compound

Procedure

introducing an acyl group at the N2 position of 1-β-D-arabinofuranosyl guanine with an acylating agent, for example, using isobutyryl chloride under conditions suitable for obtaining 1-β-D-arabinofuranosyl-N2-isobutyryl guanine,

Sources & evidence

ORD record: ord-a41b5c8804184f7f9784581d0ef09386
Source dataset: uspto-grants-2004_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06686463B2

Reaction notes

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