Acetonitrile → (1S,2S)-(-)-1-Phenylpropylene oxide

To a 100 mL three-neck round bottom flask, were added buffer (0.05 M Na2B4O7.10H2O in 4×10−4 M aq. Na2EDTA, 10 mL), acetonitrile (15 mL), trans-β-methylstyrene (0.118 g, 1 mmol), tetrabutylammonium hydrogen sulfate (0.015 g, 0.04 mmol), and ketone 1 (0.0774 g, 0.3 mmol). The reaction mixture was cooled by an ice bath. A solution of Oxone® (0.85 g, 1.38 mmol) in aq. Na2EDTA (4×10−4 M, 6.5 mL) and a solution of K2CO3 (0.8 g, 5.8 mmol) in water (6.5 mL) were added dropwise through two separate addition funnels over a period of 1.5 h (under this condition, the reaction pH is around 10.5. At this point, the reaction was immediately quenched by addition of pentane and water. The mixture was extracted with pentane (3×30 mL), washed with brine, dried over Na2SO4, purified by flash chromatography [the silica gel was buffered with 1% Et3N in pentane, pentane/ether (1/0 to 50/1, V/V) was used as eluent] to afford trans-β-methylstyrene oxide as colorless liquid (0.124 g, 93% yield, 92% ee).

1. temperatureThe reaction mixture was cooled by an ice bath
2. customseparate
3. additionaddition funnels over a period of 1.5 h (under this condition
4. customthe reaction pH is around 10.5
5. customAt this point, the reaction was immediately quenched by addition of pentane and water
6. extractionThe mixture was extracted with pentane (3×30 mL)
7. washwashed with brine
8. dry with materialdried over Na2SO4
9. custompurified by flash chromatography [the silica gel

ORD-Eintrag

ord-29772dc75052480187d426843a4c994e

Quelldatensatz

uspto-grants-2004_02

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US06686483B2