Dimethylformamide dimethyl acetal → HCID 23440965, compound

HRID 2119981Notes

Reaction equation

HRID 2119981 reaction equation
[CH3:1][C:2]1[O:6][N:5]=[C:4]([CH2:7][NH2:8])[CH:3]=1.CO[CH:11](OC)[N:12]([CH3:14])[CH3:13]>>[CH3:11][N:12]([CH3:14])[CH:13]=[N:8][CH2:7][C:4]1[CH:3]=[C:2]([CH3:1])[O:6][N:5]=1

Participants

3

Reactant 2

HCID 78373Dimethylformamide dimethyl acetalHCID 27763061-(5-Methyl-1,2-oxazol-3-yl)methanamine

Product 1

HCID 23440965HCID 23440965, compound

Procedure

A solution of the C-(5-methyl-isoxazol-3-yl)-methylamine (150 mg, 1.3 mmol) in N,N-dimethylformamide dimethylacetal (2 mL, 14.4 mmol) was heated under reflux for 3 h. After cooling to room temperature, the solvent was evaporated to leave the title compound as a yellow oil (220 mg, 98%. m/z 168.2 (MH)

Workup

  1. temperatureunder reflux for 3 h
  2. customthe solvent was evaporated

Sources & evidence

ORD record
ord-768b6cb3ca8f4ca1a9c26794e7249375
Source dataset
uspto-grants-2004_02
Patent number
US06686352B2

Reaction notes

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