Trityl chloride → HCID 23438526, compound

HRID 2120102Notes

Reaction equation

HRID 2120102 reaction equation
[N:1]1([C:7]2[N:12]=[CH:11][C:10]([I:13])=[CH:9][N:8]=2)[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.[C:14]1([C:20](Cl)([C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)[C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1.C(N(CC)CC)C>C(Cl)Cl>[C:14]1([C:20]([C:21]2[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=2)([C:27]2[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=2)[N:4]2[CH2:5][CH2:6][N:1]([C:7]3[N:8]=[CH:9][C:10]([I:13])=[CH:11][N:12]=3)[CH2:2][CH2:3]2)[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=1

Participants

5

Reactant 3

HCID 6456Trityl chlorideHCID 8471TriethylamineHCID 157298765-Iodo-2-(piperazin-1-yl)pyrimidine

Product 1

HCID 23438526HCID 23438526, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

In 100 ml of methylene chloride was dissolved 13 g of 2-piperazin-1-yl-5-iodopyrimidine which was then reacted with 15 g of triphenylmethyl chloride at room temperature for 1 hour in the presence of 16 ml of triethylamine with stirring. The reaction mixture was added with methylene chloride, after which the organic layer was washed with water and brine, dehydrated, filtered and concentrated under vacuum. The residue was purified by use of ethyl acetate and a small quantity of methanol to obtain the title compound. 10 g.

Workup

  1. washafter which the organic layer was washed with water and brine
  2. filtrationfiltered
  3. concentrationconcentrated under vacuum
  4. customThe residue was purified by use of ethyl acetate

Sources & evidence

ORD record
ord-e4b319f5f40543918700a3e5e2cf0f1a
Source dataset
uspto-grants-2004_02
Patent number
US06689779B2

Reaction notes

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