反应详情

In 10 ml of 1-methyl-2-pyrrolidone was dissolved 1.0 g of 2,5-dibromopyridine and the solution was added with 0.5 g of 1,2,3,4-tetrazole, along with 1.75 g of potassium carbonate. The reaction mixture was reacted at 100° C. for 3 hours with stirring. After completion of the reaction, the reaction mixture was added with water and extracted with ethyl acetate. The organic layer thus obtained was dehydrated, filtered and concentrated and the concentrate was subjected to column chromatography to give the title compound. 0.8 g.

1. customThe reaction mixture was reacted at 100° C. for 3 hours
2. customAfter completion of the reaction
3. extractionextracted with ethyl acetate
4. customThe organic layer thus obtained
5. filtrationfiltered
6. concentrationconcentrated