Hydrogen Bromide → HCID 23438899, compound

HRID 2120158Notes

Reaction equation

[BrH:1].C[O:3][C:4]1[CH:5]=[C:6]([C:12]2[CH:13]=[CH:14][C:15]3[C:19]([C:20]4[CH:21]=[N:22][CH:23]=[CH:24][CH:25]=4)=[CH:18][O:17][C:16]=3[CH:26]=2)[CH:7]=[CH:8][C:9]=1[O:10]C>>[BrH:1].[N:22]1[CH:23]=[CH:24][CH:25]=[C:20]([C:19]2[C:15]3[CH:14]=[CH:13][C:12]([C:6]4[CH:5]=[C:4]([OH:3])[C:9]([OH:10])=[CH:8][CH:7]=4)=[CH:26][C:16]=3[O:17][CH:18]=2)[CH:21]=1

Participants

Reactant 2

HCID 260Hydrogen Bromide

HCID 12094546HCID 12094546, compound

Product 1

HCID 23438899HCID 23438899, compoundYield 82%

Procedure

47% hydrobromic acid solution (1.6 ml) was added to 3-[6-(3,4-dimethoxyphenyl)benzo[b]furan-3-yl]pyridine (80 mg, 0.2414 mmol) obtained in Example 10, and the mixture was refluxed for 12 hours. The precipitate was filtered to obtain a pale yellow powder of 4-[3-(3-pyridyl)benzo[b]furan-6-yl]-1,2- benzenediol hydrobromide (76 mg, 82%)

Workup

temperaturethe mixture was refluxed for 12 hours
filtrationThe precipitate was filtered

Sources & evidence

ORD record: ord-4e60e5717bc946e1bbad4c1052276324
Source dataset: uspto-grants-2004_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06689798B2

Reaction notes

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