Hydrogen Peroxide → 3-Butyl-6-aminoformyl-phthalide

HRID 2120187Notes

Reaction equation

HRID 2120187 reaction equation
[CH2:1]([CH:5]1[C:14]2[C:9](=[CH:10][C:11]([C:15]#[N:16])=[CH:12][CH:13]=2)[C:7](=[O:8])[O:6]1)[CH2:2][CH2:3][CH3:4].C(=O)([O-])[O-:18].[K+].[K+].OO>CC(C)=O.O>[CH2:1]([CH:5]1[C:14]2[C:9](=[CH:10][C:11]([C:15]([NH2:16])=[O:18])=[CH:12][CH:13]=2)[C:7](=[O:8])[O:6]1)[CH2:2][CH2:3][CH3:4]

Participants

6

Reactant 3

HCID 784Hydrogen PeroxideHCID 11430Potassium CarbonateHCID 234391233-Butyl-6-cyano-phthalide

Product 1

HCID 234391073-Butyl-6-aminoformyl-phthalide

Reagents, catalysts & solvents 2

HCID 180AcetoneSolventHCID 962WaterSolvent

Procedure

To a solution of 0.8 g (3.72 mmol) of compound obtained in Example 18 in 100 ml of acetone there is added a solution of 0.55 g of potassium carbonate in 5 ml of water, to which there are added, at 20° C., 14 ml of 30% hydrogen peroxide. The mixture is put aside at room temperature overnight. The solvents are removed in vacuo and the residue is washed with water and crystallised from ethanol, giving the title compound.

Workup

  1. additionto which there are added, at 20° C.
  2. customThe solvents are removed in vacuo
  3. washthe residue is washed with water
  4. customcrystallised from ethanol

Sources & evidence

ORD record
ord-8dd93cac99384c58bd0e14ef6501c112
Source dataset
uspto-grants-2004_02
Patent number
US06689808B2

Reaction notes

Loading…