反应详情

To a solution of amino acid methyl ester VI and imidazole in DMF, is added phenylthioacetic acid followed by diisopropylcarbodiimide at room temperature. The reaction mixture is stirred for 12 hours. After filtration on silica gel pad, the filtrate is poured into water and EtOAc. The organic layer is washed twice with water, dried over Na2SO4, and concentrated to afford α-phenylthioacetamide VII.

1. filtrationAfter filtration on silica gel pad
2. additionthe filtrate is poured into water and EtOAc
3. washThe organic layer is washed twice with water
4. dry with materialdried over Na2SO4
5. concentrationconcentrated