Dimethylformamide diethylacetal → HCID 86759329, compound
Reaction equation
[C@@H:1]12[CH2:10][C@@H:5]([CH2:6][C:7](=[O:9])[NH:8]1)[CH2:4][CH2:3][C@@H:2]2[N:11]1[CH:19]=[N:18][C:17]2[C:12]1=[N:13][CH:14]=[N:15][C:16]=2[NH2:20].C(O[CH:24](OCC)[N:25]([CH3:27])[CH3:26])C>CN(C=O)C>[C@@H:1]12[CH2:10][C@@H:5]([CH2:6][C:7](=[O:9])[NH:8]1)[CH2:4][CH2:3][C@@H:2]2[N:11]1[CH:19]=[N:18][C:17]2[C:12]1=[N:13][CH:14]=[N:15][C:16]=2[N:20]=[CH:24][N:25]([CH3:27])[CH3:26]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 80 °C
Procedure
A 500 ml round-bottomed flask was loaded with 5.58 g of A lactam 15b (20 mmol), 200 ml of dry DMF and 17.1 ml of dimethylformamide diethyl acetal (100 mmol). The mixture was heated at 80° C. for 3 h. The resulting clear solution was concentrated under reduced pressure (0.4 mbar, 60° C. bath temperature) to afford 6.9 g of crude 15c, which was used without further purification.
Workup
- concentrationThe resulting clear solution was concentrated under reduced pressure (0.4 mbar, 60° C. bath temperature)
Sources & evidence
- ORD record
- ord-be558721a6fa4d1bbe6182c8298f03cc
- Source dataset
- uspto-grants-2004_02
- Patent number
- US06689884B1
Reaction notes
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