Sulfuric Acid → HCID 9928747, compound

HRID 2120422Notes

Reaction equation

HRID 2120422 reaction equation
S(=O)(=O)(O)O.C(OC[O:10][C:11]1[CH:12]=[C:13]([CH:31]=[C:32]([CH2:34][O:35]COCC)[CH:33]=1)[CH2:14][O:15][C:16]1[CH:17]=[C:18]([CH:22]([CH3:30])[CH2:23][CH2:24][CH2:25][C:26]([CH3:29])([OH:28])[CH3:27])[CH:19]=[CH:20][CH:21]=1)C>CO.C1COCC1>[OH:28][C:26]([CH3:27])([CH3:29])[CH2:25][CH2:24][CH2:23][CH:22]([C:18]1[CH:17]=[C:16]([CH:21]=[CH:20][CH:19]=1)[O:15][CH2:14][C:13]1[CH:12]=[C:11]([OH:10])[CH:33]=[C:32]([CH2:34][OH:35])[CH:31]=1)[CH3:30]

Participants

5

Reactant 2

HCID 1118Sulfuric AcidHCID 23439724HCID 23439724, compound

Product 1

HCID 9928747HCID 9928747, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolvent2×HCID 8028TetrahydrofuranSolvent

Procedure

In a manner similar to Example 1(j), by reacting 0.4 ml of concentrated sulphuric acid in 5 ml of methanol with 860 mg (1.8 mmol) of 6-[3-(3-ethoxymethoxy-5-ethoxymethoxymethylbenzyloxy)phenyl]-2-methylheptan-2-ol in 5 ml of methanol and 5 ml of THF, after purification on a silica column (ethyl acetate 60-heptane 40), a colourless oil (m=510 mg. Y=79%) is obtained.

Workup

  1. customafter purification on a silica column (ethyl acetate 60-heptane 40)
  2. customa colourless oil (m=510 mg. Y=79%) is obtained

Sources & evidence

ORD record
ord-6d63f7507fad4bb58cbfa84cfdead702
Source dataset
uspto-grants-2004_02
Patent number
US06689922B1

Reaction notes

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