Tetrabutylammonium Fluoride → HCID 57503375, compound

HRID 2120428Notes

Reaction equation

HRID 2120428 reaction equation
[F-].C([N+](CCCC)(CCCC)CCCC)CCC.[Si]([O:26][CH2:27][C:28]1[CH:29]=[C:30]([CH:48]=[CH:49][C:50]=1[CH2:51][O:52][Si](C(C)(C)C)(C)C)[O:31][CH2:32][C:33]1[CH:34]=[C:35]([CH:39]([CH3:47])[CH2:40][CH2:41][CH2:42][C:43]([CH3:46])([OH:45])[CH3:44])[CH:36]=[CH:37][CH:38]=1)(C(C)(C)C)(C)C>C1COCC1>[OH:26][CH2:27][C:28]1[CH:29]=[C:30]([CH:48]=[CH:49][C:50]=1[CH2:51][OH:52])[O:31][CH2:32][C:33]1[CH:34]=[C:35]([CH:39]([CH3:47])[CH2:40][CH2:41][CH2:42][C:43]([CH3:44])([OH:45])[CH3:46])[CH:36]=[CH:37][CH:38]=1

Participants

4

Reactant 2

HCID 2724141Tetrabutylammonium FluorideHCID 23439791HCID 23439791, compound

Product 1

HCID 57503375HCID 57503375, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

In a manner similar to Example 3(i), by reacting 1.25 ml of tetrabutylammonium fluoride with 250 mg (0.41 mmol) of 6-{3-[3,4-bis-(tert-butyldimethylsilanyloxymethyl)phenoxymethyl]phenyl}-2-methylheptan-2-ol in 7 ml of THF, after purification on a silica column (ethyl acetate 30-heptane 70), a colourless oil (m=130 mg; Y=85%) is obtained.

Workup

  1. customafter purification on a silica column (ethyl acetate 30-heptane 70)
  2. customa colourless oil (m=130 mg; Y=85%) is obtained

Sources & evidence

ORD record
ord-1b0999968aa14bd385c4b0a579998cce
Source dataset
uspto-grants-2004_02
Patent number
US06689922B1

Reaction notes

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