Acetic Acid → HCID 54545894, compound

HRID 2120438Notes

Reaction equation

HRID 2120438 reaction equation
[CH3:1][C:2]([O:26]C1CCCCO1)([CH3:25])[CH2:3][CH2:4][CH2:5][CH2:6][C:7]1[CH:12]=[CH:11][C:10]([CH:13]=[CH:14][CH:15]2OCC3C=CC=CC=3O2)=[CH:9][CH:8]=1.[C:33]([OH:36])(=O)[CH3:34].[CH2:37]1[CH2:41][O:40][CH2:39][CH2:38]1>O>[OH:40][CH2:39][C:38]1[CH:37]=[CH:41][C:15]([CH:14]=[CH:13][C:10]2[CH:9]=[CH:8][C:7]([CH2:6][CH2:5][CH2:4][CH2:3][C:2]([OH:26])([CH3:1])[CH3:25])=[CH:12][CH:11]=2)=[CH:34][C:33]=1[OH:36]

Participants

5

Reactant 3

HCID 176Acetic AcidHCID 8028TetrahydrofuranHCID 86759336HCID 86759336, compound

Product 1

HCID 54545894HCID 54545894, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

In a manner similar to Example 8(k), by reacting 2 g (4.3 mmol) of 2,2-dimethyl-7-(2-{4-[5-methyl-5-(tetrahydropyran-2-yloxy)hexyl]phenyl}vinyl-4H-benzo[1,3]dioxin in a solution of 50 ml of acetic acid+25 ml of THF+12.5 ml of water, after purification on a silica column (ethyl acetate 50-heptane 50), a white powder (m=44 mg; Y=3%) is obtained. m.p.=163-5° C.

Workup

  1. customafter purification on a silica column (ethyl acetate 50-heptane 50)
  2. customa white powder (m=44 mg; Y=3%) is obtained

Sources & evidence

ORD record
ord-f741506af26940daa7b23d8c42d6ef0d
Source dataset
uspto-grants-2004_02
Patent number
US06689922B1

Reaction notes

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