Sulfuric Acid → HCID 57097596, compound

HRID 2120440Notes

Reaction equation

HRID 2120440 reaction equation
S(=O)(=O)(O)O.[OH:6][CH2:7][C:8]1[CH:13]=[CH:12][C:11]([CH:14]=[CH:15][C:16]2[CH:21]=[CH:20][CH:19]=[C:18]([CH2:22][CH2:23][CH2:24][CH2:25][C:26]([CH3:35])([O:28]C3CCCCO3)[CH3:27])[CH:17]=2)=[CH:10][C:9]=1[CH2:36][OH:37]>C1COCC1.O>[OH:37][CH2:36][C:9]1[CH:10]=[C:11]([CH:14]=[CH:15][C:16]2[CH:17]=[C:18]([CH2:22][CH2:23][CH2:24][CH2:25][C:26]([CH3:35])([OH:28])[CH3:27])[CH:19]=[CH:20][CH:21]=2)[CH:12]=[CH:13][C:8]=1[CH2:7][OH:6]

Participants

5

Reactant 2

HCID 1118Sulfuric AcidHCID 57021021HCID 57021021, compound

Product 1

HCID 57097596HCID 57097596, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolvent2×HCID 8028TetrahydrofuranSolvent

Conditions

Temperature
40 °C

Procedure

0.09 ml of concentrated sulphuric acid are added to 44 mg (0.1 mmol) of [2-hydroxymethyl-5-(2-{3-[5-methyl-5-(tetrahydropyran-2-yloxy)hexyl]-phenyl}vinyl)phenyl]methanol in 1 ml of THF and 1 ml of water. The solution is heated at 40° C. for 48 hours. Water is added and the mixture is extracted with ether. The organic phase is dried over magnesium sulphate and concentrated. The product is triturated in an ether-hexane mixture and is then filtered and dried.

Workup

  1. extractionthe mixture is extracted with ether
  2. dry with materialThe organic phase is dried over magnesium sulphate
  3. concentrationconcentrated
  4. customThe product is triturated in an ether-hexane mixture
  5. filtrationis then filtered
  6. customdried

Sources & evidence

ORD record
ord-1f24f6974d464bfa92676d7f892af8bc
Source dataset
uspto-grants-2004_02
Patent number
US06689922B1

Reaction notes

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