Tetrabutylammonium Fluoride → HCID 56991338, compound

HRID 2120443Notes

Reaction equation

HRID 2120443 reaction equation
[Si]([O:8][C:9]1[CH:10]=[C:11]([C:23]([CH3:40])=[CH:24][C:25]2[CH:26]=[C:27]([CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][C:36]([CH3:39])([OH:38])[CH3:37])[CH:28]=[CH:29][CH:30]=2)[CH:12]=[C:13]([O:15][Si](C(C)(C)C)(C)C)[CH:14]=1)(C(C)(C)C)(C)C.[F-].C([N+](CCCC)(CCCC)CCCC)CCC>C1COCC1>[OH:38][C:36]([CH3:39])([CH3:37])[CH2:35][CH2:34][CH2:33][CH2:32][CH2:31][C:27]1[CH:26]=[C:25]([CH:24]=[C:23]([C:11]2[CH:10]=[C:9]([OH:8])[CH:14]=[C:13]([OH:15])[CH:12]=2)[CH3:40])[CH:30]=[CH:29][CH:28]=1

Participants

4

Reactant 2

HCID 2724141Tetrabutylammonium FluorideHCID 69685427HCID 69685427, compound

Product 1

HCID 56991338HCID 56991338, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

In a manner similar to Example 3(i), by reacting 402 mg (0.69 mmol) of 7-(3-{2-[3,5-bis(tert-butyldimethylsilanyloxy)phenyl]propenyl}phenyl)-2-methylheptan-2-ol with 1.4 ml of tetrabutylammonium fluoride 1M/THF, after purification on a silica column (ethyl acetate 40-heptane 60), white crystals (m=176 mg; Y=72%) are obtained. m.p. 113-4° C.

Workup

  1. customafter purification on a silica column (ethyl acetate 40-heptane 60), white crystals (m=176 mg; Y=72%)
  2. customare obtained

Sources & evidence

ORD record
ord-3c98958ad196418588f89124bc6bc394
Source dataset
uspto-grants-2004_02
Patent number
US06689922B1

Reaction notes

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