Tetrabutylammonium Fluoride → HCID 56997199, compound

HRID 2120449Notes

Reaction equation

HRID 2120449 reaction equation
[Si]([O:8][C:9]1[CH:10]=[C:11]([CH:15]=[CH:16][C:17]2[CH:18]=[C:19]([CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][C:29]([CH3:32])([OH:31])[CH3:30])[CH:20]=[CH:21][CH:22]=2)[CH:12]=[CH:13][CH:14]=1)(C(C)(C)C)(C)C.[F-].C([N+](CCCC)(CCCC)CCCC)CCC>C1COCC1>[OH:31][C:29]([CH3:32])([CH3:30])[CH2:28][CH2:27][CH2:26][CH2:25][CH2:24][CH2:23][C:19]1[CH:18]=[C:17]([CH:16]=[CH:15][C:11]2[CH:10]=[C:9]([OH:8])[CH:14]=[CH:13][CH:12]=2)[CH:22]=[CH:21][CH:20]=1

Participants

4

Reactant 2

HCID 2724141Tetrabutylammonium FluorideHCID 57275873HCID 57275873, compound

Product 1

HCID 56997199HCID 56997199, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

In a manner similar to Example 3(i), by reacting 207 mg (0.46 mmol) of 8-(3-{2-[3-(tert-butyldimethylsilanyloxy)phenyl]vinyl}phenyl)-2-methyloctan-2-ol with 0.5 ml of tetrabutylammonium fluoride 1M/THF, after purification on a silica column (ethyl acetate 30-heptane 70), a white powder (m=203 mg; Y=32%) is obtained. m.p.=142-3° C.

Workup

  1. customafter purification on a silica column (ethyl acetate 30-heptane 70)
  2. customa white powder (m=203 mg; Y=32%) is obtained

Sources & evidence

ORD record
ord-75215a3de9454e259b43e97019ade51a
Source dataset
uspto-grants-2004_02
Patent number
US06689922B1

Reaction notes

Loading…