Tetrabutylammonium Fluoride → HCID 57503378, compound

HRID 2120454Notes

Reaction equation

HRID 2120454 reaction equation
[Si]([O:8][CH2:9][C:10]1[CH:11]=[C:12]([C:25]#[C:26][C:27]2[CH:28]=[C:29]([CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][C:38]([CH3:41])([OH:40])[CH3:39])[CH:30]=[CH:31][CH:32]=2)[CH:13]=[CH:14][C:15]=1[CH2:16][O:17][Si](C(C)(C)C)(C)C)(C(C)(C)C)(C)C.[F-].C([N+](CCCC)(CCCC)CCCC)CCC>C1COCC1>[OH:8][CH2:9][C:10]1[CH:11]=[C:12]([C:25]#[C:26][C:27]2[CH:28]=[C:29]([CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][C:38]([CH3:41])([OH:40])[CH3:39])[CH:30]=[CH:31][CH:32]=2)[CH:13]=[CH:14][C:15]=1[CH2:16][OH:17]

Participants

4

Reactant 2

HCID 2724141Tetrabutylammonium FluorideHCID 23439822HCID 23439822, compound

Product 1

HCID 57503378HCID 57503378, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

In a manner similar to Example 3(i), by reacting 250 mg (0.42 mmol) of 7-{3-[3,4-bis-(tert-butyldimethylsilanyloxymethyl)phenylethynyl]phenyl}-2-methylheptan-2-ol with 0.93 ml of tetrabutylammonium fluoride 1M/THF, after purification on a silica column (ethyl acetate 70-heptane 30), white crystals (m=132 mg; Y=86%) are obtained. m.p.=52-5° C.

Workup

  1. customafter purification on a silica column (ethyl acetate 70-heptane 30), white crystals (m=132 mg; Y=86%)
  2. customare obtained

Sources & evidence

ORD record
ord-4fec816dcb0347e9b8046246bd88716d
Source dataset
uspto-grants-2004_02
Patent number
US06689922B1

Reaction notes

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