Methanol → HCID 57100366, compound

HRID 2120457Notes

Reaction equation

HRID 2120457 reaction equation
S(=O)(=O)(O)O.C(OC[O:10][C:11]1[CH:12]=[C:13]([CH:22]=[CH:23][C:24]2[CH:25]=[C:26]([C:30]([OH:47])([CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][C:37]([CH3:46])([O:39]C3CCCCO3)[CH3:38])[CH3:31])[CH:27]=[CH:28][CH:29]=2)[CH:14]=[C:15]([O:17]COCC)[CH:16]=1)C.[CH3:48]O>C1COCC1>[OH:39][C:37]([CH3:38])([CH3:46])[CH2:36][CH2:35][CH2:34][CH2:33][CH2:32][C:30]([C:26]1[CH:25]=[C:24]([CH:23]=[CH:22][C:13]2[CH:14]=[C:15]([OH:17])[CH:16]=[C:11]([OH:10])[CH:12]=2)[CH:29]=[CH:28][CH:27]=1)([O:47][CH3:48])[CH3:31]

Participants

5

Reactant 3

HCID 887Methanol2×HCID 1118Sulfuric AcidHCID 57247486HCID 57247486, compound

Product 1

HCID 57100366HCID 57100366, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

In a manner similar to Example 1(j), by reacting 0.2 ml of concentrated sulphuric acid in 3 ml of methanol with 350 mg (0.6 mmol) of 2-{3-[2-(3,5-bis-ethoxymethoxyphenyl)vinyl]phenyl}-8-methyl-8-(tetrahydropyran-2-yloxy)nonan-2-ol in 3 ml of methanol and 3 ml of THF, after purification on a silica column (ethyl acetate 60-heptane 40), white crystals (m=76 mg; Y=32%) are obtained. m.p.=65-75° C.

Workup

  1. customafter purification on a silica column (ethyl acetate 60-heptane 40), white crystals (m=76 mg; Y=32%)
  2. customare obtained

Sources & evidence

ORD record
ord-fd1356725d604310a7d60569ecb99b59
Source dataset
uspto-grants-2004_02
Patent number
US06689922B1

Reaction notes

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