Sulfuric Acid → HCID 67278647, compound

HRID 2120463Notes

Reaction equation

HRID 2120463 reaction equation
S(=O)(=O)(O)O.C(OC[O:10][C:11]1[CH:12]=[C:13]([CH:22]=[CH:23][C:24]2[CH:25]=[C:26]([C:30]([OH:46])([CH2:32][CH2:33][CH2:34][CH2:35][C:36]([CH3:45])([O:38]C3CCCCO3)[CH3:37])[CH3:31])[CH:27]=[CH:28][CH:29]=2)[CH:14]=[C:15]([O:17]COCC)[CH:16]=1)C>CO.C1COCC1>[OH:46][C:30]([C:26]1[CH:25]=[C:24]([CH:23]=[CH:22][C:13]2[CH:12]=[C:11]([OH:10])[CH:16]=[C:15]([OH:17])[CH:14]=2)[CH:29]=[CH:28][CH:27]=1)([CH3:31])[CH2:32][CH2:33][CH2:34][CH2:35][C:36]([OH:38])([CH3:45])[CH3:37]

Participants

5

Reactant 2

HCID 1118Sulfuric AcidHCID 69686234HCID 69686234, compound

Product 1

HCID 67278647HCID 67278647, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 8028TetrahydrofuranSolvent

Procedure

In a manner similar to Example 1(j), by reacting 0.6 ml of concentrated sulphuric acid in 7.5 ml of methanol with 369 mg (0.65 mmol) of 2-{3-[2-(3,5-bis-ethoxymethoxyphenyl)vinyl}phenyl}-7-methyl-7-(tetrahydropyran-2-yloxy)octan-2-ol in 7.4 ml of THF, after purification on a silica column (ethyl acetate 70-heptane 30), a yellowish paste (m=220 mg; Y=92%) is obtained.

Workup

  1. customafter purification on a silica column (ethyl acetate 70-heptane 30)
  2. customa yellowish paste (m=220 mg; Y=92%) is obtained

Sources & evidence

ORD record
ord-18628a45159c4909ba4d0781474fb709
Source dataset
uspto-grants-2004_02
Patent number
US06689922B1

Reaction notes

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