反应详情

A total of 10 mmole of acrylyl chloride was added dropwise to a mixture of 10 mmole of 3-hydroxy-α-isopropyl-α-methyl-1-adamantanemethanol thus obtained, 10 mmole of triethylamine and 40 ml of tetrahydrofuran over about 30 minutes. After the completion of addition, the resulting mixture was stirred at room temperature for 6 hours. After adding water, the reaction mixture was concentrated, and the concentrate was subjected to column chromatography on a silica gel to thereby yield the title compound in a yield of 67%.

1. customthus obtained
2. additionAfter the completion of addition
3. concentrationthe reaction mixture was concentrated